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Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system illness caused by exposure to biotoxins, often from mould, water-damaged buildings, or other environmental sources. For many, the symptoms are persistent, wide-ranging, and resistant to conventional treatment. If you’ve been living with unexplained fatigue, brain fog, chronic pain, or mood disturbances, CIRS could be the underlying cause.
Anyone can develop chronic inflammatory response syndrome, or CIRS, but certain factors increase vulnerability. People who spend time in damp or water-damaged buildings are at higher risk due to ongoing exposure to mould-related biotoxins. Some individuals also carry genetic patterns that make it harder for the body to clear these toxins, leading to persistent symptoms. Those with recurring sinus problems, unexplained fatigue, cognitive changes, or symptoms that fluctuate depending on their environment may fall into higher-risk groups. At Greenland Medical, we also see increased susceptibility among people with repeated infections or high stress levels. Those with a history of environmental sensitivities can be at risk as well. Understanding these patterns helps us tailor CIRS treatment more precisely.



There are simple actions you can take while preparing for your consultation. Tracking your symptoms when they improve, worsen, or change can help you identify environmental triggers. If you suspect mould exposure, improving airflow, reducing humidity, and avoiding visibly affected areas may reduce ongoing irritation. Keeping a record of sleep, energy levels, headaches, or cognitive changes provides valuable context for your clinician. Staying hydrated, prioritizing rest, and limiting unnecessary chemical exposures can also support your body’s natural recovery processes. These steps are not a replacement for medical care, but they help make your first visit more productive and informative. Currently, CIRS isn't universally accepted in UK mainstream medicine, but our clinic will work to provide you with the support you need.
Your initial consultation at Greenland Medical is structured to be thorough and calm. We begin by reviewing your medical history, current symptoms, and any environmental concerns. Your clinician will explain how functional medicine approaches complex, multi-system conditions and outline which diagnostic tests may be appropriate. These may include VCS, C4a, TGF-β1, MSH, MMP-9, and HLA-DR, which can involve blood markers, inflammation profiles, or environmental assessments. You will have time to ask questions and understand the reasoning behind each step. Book an appointment with our clinic and begin your healing journey.


CIRS affects how your immune system responds to biotoxins, triggering a cascade of inflammation that disrupts your brain, hormones, immune system, and energy production. Because it doesn’t show up on standard tests, many patients are told “everything looks normal” despite feeling far from well. Left untreated, CIRS can become a chronic, life-altering condition.
Many patients with long-standing symptoms can find support at our clinic. We take a different approach. Our clinicians provide clear explanations, steady guidance, and space to discuss both physical and emotional concerns. We use longer appointment times when needed, review results in detail, and help you understand how each part of your plan fits together. Throughout your CIRS treatment, we aim to create an environment where you feel heard, respected, and supported. This combination of clinical expertise and compassionate care can be valuable to patients across London. If you’re ready to explore a personalised approach to chronic inflammatory response syndrome, you can contact us to book your appointment and begin your assessment.



Led by Dr Andrew Greenland, a specialist in functional medicine with expertise in complex, environmentally acquired illness

Grounded in the latest clinical protocols for biotoxin illness and neuroimmune conditions

Focused on root cause resolution, not just symptom management

Compassionate care that respects your experience and your autonomy
CIRS symptoms include fatigue, brain fog, headaches, chronic pain, mood changes, sleep problems, and hormonal imbalances. Symptoms often persist despite standard treatments.
The Shoemaker Protocol is a step-by-step treatment framework for CIRS. It focuses on removing ongoing exposure, supporting detox pathways, restoring energy production, and correcting imbalances. Each step is adapted to your specific case.
Yes. Children can be affected by biotoxin exposure in homes, schools, or daycare environments. Symptoms in children may include fatigue, poor concentration, mood changes, and frequent illness.
The length of treatment varies. Some people notice improvement within weeks, while others need months of stepwise care. The pace depends on your exposure, lab findings, and individual response to treatment.
Recovery is possible with the right steps. If exposure is avoided and treatment is followed, many patients regain health and function. Continued monitoring helps reduce the risk of relapse.
Yes. Biotoxins can be present even when a building shows no obvious signs of damage.
Timelines vary, but patients often see improvement as each step of their plan is completed.
No. It involves immune dysregulation rather than a typical allergic response.
Yes. Environmental adjustments, sleep support, and stress management can complement medical care.